Work

Chronic AT 1 blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats

Year: 2021

Type: article

Abstract: Inappropriate activation of the renin-angiotensin system increases adipocyte inflammation contributing to the impairment in adipocyte function and increases hepatic PCK1 and G6PC1 mRNA expression in response to a glucose challenge. Ultimately, these effects may contribute to the development of glucose intolerance.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00584.2020

Authors: Ruben Rodriguez, Andrew Y. Lee, Jose A. Godoy-Lugo, Bridget Martinez, Hiroyuki Ohsaki, Daisuke Nakano, David G. Parkes, Akira Nishiyama, José Pablo Vázquez-Medina, Rudy M. Ortiz

Institutions: University of California, Merced, Kobe University, Kagawa University, University of California, Berkeley

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Agriculture, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute on Minority Health and Health Disparities

Awards: G1925151583, G5907180037, UCSC MHIRT Research Training Grant, Mechanisms of Oxidative Stress and Inflammation during Prolonged Fasting and Slee, Independent Scientist Development Award in Oxidative Stress and Apnea, G899655116, The UCSF IRACDA Scholars Program.

OpenAlex ID: W3205319683

FWCI: 0.72

Cites: 62

Cited by: 9

Related to: 10