Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda
Year: 2021
Type: review
Abstract: Autism spectrum disorder (ASD) impacts an individual's ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD).
Institutions: University of North Carolina at Chapel Hill, Columbia University, Kennedy Krieger Institute, Johns Hopkins University, Johns Hopkins Medicine, University of Washington, University of Alberta, University of California San Diego, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Brown University, University of Minnesota, University of California, Davis
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Awards: G190946354, G2800932290, Development and neural mechanisms of repetitive behavior and sensory responsivity in autism, G4884579060, Intellectual and Developmental Disabilities Research Center, Clinical Translational Research Center for Neurodevelopmental Disorders, MIND Institute Intellectual and Developmental Disabilities Research Center, North Carolina Translational and Clinical Science Institute (NC TraCS) KL2, MRI Based Presymptomatic Prediction of ASD, Postdoctoral Research in Neurodevelopmental Disorders
OpenAlex ID: W3205598152