Work

LncRNA-MIAT regulates the growth of SHSY5Y cells by regulating the miR-34-5p-SYT1 axis and exerts a neuroprotective effect in a mouse model of Parkinson's disease.

Year: 2021

Type: article

Abstract: , compared with the NC group, the overexpression of MIAT resulted in an increase in the positive rates of Parkin and TH, and the apoptosis was decreased in the PD mice. The behavioral test results showed that the motor coordination and autonomous activity of the mice were enhanced in the MIAT overexpression group compared with the NC group. LncRNA-MIAT regulates the growth of SHSY5Y cells by sponging miR-34-5p which targets SYT1 and exerts a neuroprotective effect in a mouse model of PD.

Source: American Journal of Translational Research

Authors: Yue'e Shen, Xintao Cui, Yuhang Hu, Zhizhuang Zhang, Zhenyu Zhang

Institutions: Harbin Medical University, First Affiliated Hospital of Harbin Medical University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3206138059

FWCI: 1.991

Cites:

Cited by: 18

Related to: 9