Year: 2021
Type: dissertation
Abstract: Wounds in the eardrum fail to heal in some patients, leaving the ear susceptible to infection and damage, causing long-term hearing loss. Investigating therapeutics options, mesenchymal stem cells were found to secrete signalling factors that stimulate wound healing in eardrum cells. Wound healing was also stimulated in skin and lung cell cultures in similar way. Further investigations found that wound healing effects of the signalling factors increased by growing the stem cells in low oxygen, on biomaterials and in 3D environments. In the future, this new therapy promises relief for patients with chronic eardrum wounds and other chronic wound types.
DOI: 10.26182/hh2q-0641
Author: Ong, Huan Ting
Institution: The University of Western Australia
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3207124110