Vitamin D3 and Selenium Supplementation and Renal Hyper-filtration State in Metabolic Syndrome Patients
Year: 2021
Type: conference-paper
Abstract: Objective: This work aimed to study the effect of supplanting vitamin D3 and selenium on the renal-filtration status and glycosylation-gap in metabolic syndrome patients.Subjects and methods: This pre-post study conducted on 93 patients referred from different general /or private internal medicine clinics with metabolic syndrome to the Soran private laboratory-Erbil.Patients present with at least three of five criteria of metabolic syndrome according to NCEP ATP III.Vitamin D estimation using the enzyme-linked fluorescent assay (ELFA) technique.Mitochondrial function analysis involved measurement of serum lactate and serum pyruvate by fluorescence-based methods.L-Carnitine was assayed using colourimetric /fluoro-metric.e-GFR calculated by equation.Results: The results shows that metabolic syndrome patient supplementing with vitamin D3 and selenium significantly elevated serum Vitamin D3 that associated with reduction in both systolic and diastolic blood pressure (p<0.001).HbA1c, serum fructosamine, Glycosylation gap also significant reduction (p<0.001).Serum triglycerides significantly decrease (p<0.001) with a significant increase in HDL-C (p<0.001).Renal function profile shows that serum creatinine significantly elevated after the treatment in contrast e-GFR, urinary albumin and Albumin/ creatinine ratio reduced after the treatment (p< 0.001).Mitochondrial function profile shows that after supplements treatment, mitochondrial function parameters return to normal values in comparison to before treatment (p<0.001).Conclusion: supplementing vitamin D3 and Selenium to metabolic syndrome patient significantly reduce hyper-filtration status by activating mitochondrial function in these patients, so it can used as a protective measure in the treatment of metabolic syndrome patients.
Author: Muhammad A. Ahmed
Institution: Ninevah University
Language: English
Topic: Vitamin D Research Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3207717873