Post-renal transplantation metabolic complications in the nephrology department of CHU Batna 2017-2019
Year: 2021
Type: article
Study design: Observational Study
Abstract: Renal transplantation (RT) is burdened with various metabolic complications - diabetes, dyslipidaemia, hyperuricaemia and obesity - largely related to immunosuppressive therapy, which constitute a risk factor for morbidity and graft function loss. The aim of our study is to evaluate the frequency and profile of these abnormalities after RT. Our work is prospective and descriptive, where all patients transplanted in our department since January 2015 were included. We recorded the demographic and clinicobiological data of the recipient as well as the prescribed immunosuppressive treatment. One hundred and three patients were included, with a mean age of 36±5 years, with a M/F sex ratio of 2.55. Seventy-three of our patients (70.9%) were hypertensive before RT and 2.9% were diabetic. The immunosuppressive treatment prescribed during the induction phase was thymoglobulin in 78.6% of cases and basiliximab in 21.4%. In the maintenance phase: all patients were on steroids, tacrolimus was prescribed in 58.3%, the rest were on cyclosporine. Mycophenolate mofetil was prescribed in 96.1% and azathioprine in 3.9%. The mean BMI was 27.9±2.4; 41% of the patients were overweight, of which 33.5% were obese. Hypercholesterolaemia was observed in 41.31% of patients and high hyperuricaemia in 27%. Twenty-four patients developed diabetes after RT after 24 months of follow-up, i.e. 23.76% of cases. Graft loss was noted in one patient and one patient died with a functional graft. Metabolic complications after RT are frequent. Early patient education is a priority. It must be based on a multidisciplinary approach involving dieticians, psychologists, general practitioners and transplant associations.
Language: French
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3208559543