Work

Recurrent pneumothoraces with diffuse small ground‐glass and solid nodules

Year: 2021

Type: article

Abstract: Multifocal micronodular pneumocyte hyperplasia (MMPH) is the lesser known pulmonary manifestation of tuberous sclerosis. It manifests radiologically as diffuse small ground-glass and solid nodules. Accurate diagnosis is essential as it can be mistaken for miliary tuberculosis or malignant lesions which necessitates specific treatment. Constellation of radiological features such as multicentric disease at onset and stability over time can help to distinguish MMPH from its differentials. Histologically, MMPH is characterized by hamartomatous proliferation of type II pneumocytes with a lack of high nuclear to cytoplasmic ratio. MMPH confers a benign prognosis unlike its differentials. Therefore, accurate diagnosis is paramount in ensuring appropriate care is delivered. Here, we describe the radiological and histological features of MMPH in a patient with genetically proven tuberous sclerosis complex and co-existing lymphangioleiomyomatosis.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.870

Authors: Li Yan Sandra Hui, Xin Min Cheng, Ing Xiang Soo, Su Ying Low

Institutions: Changi General Hospital, Singapore General Hospital, National Heart Centre Singapore

Language: English

Topic: Tuberous Sclerosis Complex Research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000