Work

From groove binding to intercalation: unravelling the weak interactions and other factors modulating the modes of interaction between methylated phenanthroline-based drugs and duplex DNA

Year: 2021

Type: article

Abstract: groove binding thus making the transition to the intercalation cytotoxic mode difficult. Looking at the NCI results, these interactions come not only from the CH/π and CH/n interactions of the methyl group in position 4 but also from the ethylenediamine (en) ligand, whose orientation in the Pt complex was found in such a way that it produces a high number of weak interactions with DNA, especially with the sugar and phosphate backbone.

Source: Physical Chemistry Chemical Physics

DOI: 10.1039/d1cp04529f

Authors: Ángel Sánchez-González, Tarsila G. Castro, Manuel Melle-Franco, Adrià Gil

Institutions: University of Lisbon, University of Minho, University of Aveiro, CIC nanoGUNE

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Diputación Foral de Gipuzkoa, Fundação para a Ciência e a Tecnologia