Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification
Year: 2021
Type: article
Study design: Observational Study
Abstract: AIMS: The roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression. METHODS: A total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of ＞10 Agatston units (AU) among men with 0＜CAC＜100 AU at baseline, that of ＞10% among those with CAC ≥ 100 AU, and any progression for those with CAC=0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model. RESULTS: ) (RR: 1.27; 1.05 to 1.53; p=0.012) remained significant after adjustments for age, the follow-up time, and computerized tomography type. Following further adjustments for hypertension, diabetes mellitus, dyslipidemia, C-reactive protein, and lifestyle factors, CAC progression was associated with albuminuria (RR: 1.20; 1.01 to 1.43; p=0.04) and low eGFRcys (RR: 1.19; 0.99 to 1.43; p=0.066), but not with eGFRcre. CONCLUSION: CAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.
DOI: 10.5551/jat.63030
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: Association of glycemic variability with cognitive function and subclinical atherosclerosis in a general population of Japanese women, International comparison of subclinical atherosclerosis among the Japanese and American men aged 40-49, Association between equol, a metabolite of soy protein, and atherosclerosis in a community-based general population, A study on determinants of subclinical atherosclerosis, Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men, Subclinical atherosclerosis and brain atrophy in general Japanese women : the second phase survey, The association of sub-clinical atherosclerosis and estimated glomelular filtration rate with albuminuria among general Japanese., International collaborative study on subclinical atherosclerosis and its risk factors in three populations in the US and Japan, Explorative Study on new biomarker of atherosclerosis, Association between renal sinus fat volume and metabolic factors in Japanese men
OpenAlex ID: W3210095352