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COVID-19 mRNA Vaccine-induced Pneumonitis

Year: 2021

Type: article

Abstract: A 65-year-old man experienced cough and shortness of breath 3 days after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray revealed bilateral infiltrates, and the desaturation deteriorated rapidly. The symptoms and radiographic abnormalities rapidly improved after the initiation of corticosteroid therapy. Intradermal testing of the Pfizer-BioNTech COVID-19 vaccine showed a delayed positive reaction. Based on these findings, the patient was diagnosed with COVID-19 vaccine-induced pneumonitis. The timing of the onset of pneumonitis after vaccination and the results of intradermal testing suggest that Type IV hypersensitivity against COVID-19 vaccine may have been responsible for this clinical condition.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.8310-21

Authors: Shinichi Matsuzaki, Hiroyuki Kamiya, Ichiro Inoshima, Yasutaka Hirasawa, Osamu Tago, Masashi Arai

Institutions: Tatebayashi Kosei General Hospital, International University of Health and Welfare

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Pfizer