Work

Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)

Year: 2021

Type: article

Abstract: Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.

Source: International Journal of Cardiovascular and Thoracic Surgery

DOI: 10.11648/j.ijcts.20210705.11

Authors: Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman

Institutions: National University, University of Dongola, Al Fajr College of Science and Technology

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3210186950