Year: 2021
Type: review
Abstract: Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.
Source: Cancers
Institutions: National and Kapodistrian University of Athens, Academy of Athens, Biomedical Research Foundation of the Academy of Athens, University of West Attica, Alexander Fleming Biomedical Sciences Research Center, Alexandra Hospital, Manchester Academic Health Science Centre, University of Surrey, University of Manchester, Cancer Research UK Manchester Centre
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,376
Award: G2669800405
OpenAlex ID: W3210249124