Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
Year: 2021
Type: article
Study design: Case Report
Abstract: We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
Authors: Stephanie L.S. Penetra, Michele F.B. da Silva, Paola Resende, Anielle Pina-Costa, Heloisa F.P. Santos, Lusiele Guaraldo, Guilherme A. Calvet, Maria Ogrzewalska, Ighor Arantes, Ketiuce Zukeram, Mia F. de Araújo, Ana Beatriz Machado Lima, Renata Serrano Lopes, Larissa R. Lira-Silva, Isabella V. Moraes, Mayumi D. Wakimoto, Trevon L. Fuller, Claudia Raja Gabaglia, Otávio M. Espíndola, Myrna C. Bonaldo, Cláudio Tadeu Daniel-Ribeiro, Jimmy Whitworth, Chris Smith, Karin Nielsen-Saines, Alex Pauvolid-Correa, Marilda M. Siqueira, Patricia Brasil
Institutions: Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Centro Universitário Serra dos Órgãos, University of California, Los Angeles, Biomedical Research Institute of Southern California, London School of Hygiene & Tropical Medicine, Texas A&M University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,750
Funders: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Ministério da Saúde, Ministério da Ciência, Tecnologia, Inovações e Comunicações, Instituto Nacional de Ciência e Tecnologia de Fluidos Complexos, National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases
Awards: Household Transmission and Immunity to SARS-CoV-2 among Paediatric Clients of a Primary Care Center in a Low-resource Community in Rio de Janeiro, G1825752243, G1840770272, G228631196, G2311368543, G3744854919, G3881975835, G4125498800, G5157461147, G5514976981, G6172025868, Viral kinetics, immunity and transmission of ZIKV: an exploratory analysis in preparation for vaccine development, G691015304, G7958532351, G8221555982, G8240265164, G8522711164, Genetic evolution, pathogenesis and immune responses in mother to child transmission of ZIKV
OpenAlex ID: W3210569293