Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder
Year: 2021
Type: article
Study design: Observational Study
Abstract: The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Source: Brain Sciences
Authors: Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola
Institutions: University of Oulu, University of Cambridge, Cambridge Cognition (United Kingdom), University of Helsinki, Helsinki University Hospital, Finnish Institute for Health and Welfare, University of Eastern Finland, Niuvanniemi Hospital, Institute for Molecular Medicine Finland, University of Turku, Turku University Hospital, Tampere University, Pirkanmaa Hospital District, University of Tampere, City of Helsinki, Karolinska Institutet, Oulu University Hospital, Infotech Oulu, Broad Institute, Harvard University, Massachusetts General Hospital, Stanley Center for Psychiatric Research, Massachusetts Institute of Technology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,137
OpenAlex ID: W3211065308