Reduced Peripheral and Inspiratory Muscle Endurance in Patients With Liver Cirrhosis: a Cross-sectional Study
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Liver cirrhosis (LC) causes several musculoskeletal changes. OBJECTIVE: To test the hypothesis that the peripheral and inspiratory muscle endurance are reduced in patients with liver cirrhosis. METHODS: Twenty-one patients with LC (LC group; 61±14 years) and 18 age-matched subjects (control group; 56±17 years) had accepted to participate in this cross-sectional observational study. To assess peripheral muscle endurance, all volunteers performed a rhythmic handgrip exercise at 45% of their maximum voluntary contraction. A metronome was used to control the contraction-relaxation cycles at 60/min. The inspiratory muscle endurance was assessed using PowerBreath®. Participants underwent inspiratory muscle exercise at 60% of their maximal inspiratory muscle strength. The time until failure characterized the muscle endurance for both handgrip and inspiratory muscle exercises. Additionally, the quality of life of the participants was assessed. RESULTS: The muscle endurance was lower in the LC group when compared to the control group for both handgrip (67 vs 130 s, P<0.001) and inspiratory muscle exercises (40 vs 114 s, P<0.001). The peripheral muscle endurance was directly correlated with the total quality of life score (r=0.439, P=0.01) and to the following domains: fatigue (r=0.378 e P=0.030), activity (r=0.583, P=0.001), systemic symptoms (r=0.316, P=0.073) and preoccupation (r=0.370, P=0.034). The inspiratory muscle endurance was inversely correlated with the total quality of life score (r=0.573, P=0.001) and the following domains: fatigue (r=0.503, P=0.002), activity (r=0.464, P=0.004), systemic symptoms (r=0.472, P=0.004), abdominal symptoms (r=0.461, P=0.005), emotional function (r=0.387, P=0.02) and preoccupation (r=0.519, P=0.001). CONCLUSION: Both peripheral and inspiratory muscle endurance were lower in LC patients when compared to the control group.
Source: Arquivos de Gastroenterologia
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G1426168670, G1686041357, G1840770272, G2126507314, EFEITOS DO TREINAMENTO FÍSICO AERÓBICO E TREINAMENTO MUSCULAR INSPIRATÓRIO EM PACIENTES INTERNADOS PARA TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOIÉTICAS, G29316538, EFEITOS DO EXERCÍCIO FÍSICO NO CONTROLE AUTONÔMICO, HEMODINÂMICO E VASCULAR DE INDIVÍDUOS TABAGISTAS., G7550877587
OpenAlex ID: W3211257149