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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca 2+ signaling during T cell activation

Year: 2021
Type: article
Abstract: signaling between 4 and 12 min after stimulation. Our findings suggest that a DUOX2- and G6PD-catalyzed redox cycle rapidly produces and degrades NAADP through NAADPH as an inactive intermediate.
DOI: 10.1126/scisignal.abe3800
Authors: Feng Gu, Aileen Krüger, Hannes G. Roggenkamp, Rick Alpers, Dmitri Lodygin, Vincent Jaquet, Franziska Möckl, Lola C. Hernandez C., Kai Winterberg, Andreas Bauche, Anette Rosche, Helmut Grasberger, John Y. Kao, Daniel Schetelig, René Werner, Katrin Schröder, Michael Carty, Andrew G. Bowie, Samuel Huber, Chris Meier, Hans-Willi Mittrücker, Joerg Heeren, Karl-Heinz Krause, Alexander Flügel, Björn-Philipp Diercks, Andreas H. Guse
Institutions: University Medical Center Hamburg-Eppendorf, Universitätsmedizin Göttingen, University of Geneva, University of Michigan, Michigan Medicine, Goethe University Frankfurt, Trinity College Dublin, Universität Hamburg
Language: English
Subfield: Physiology
Open Access status: green
Funders: National Science Foundation, Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Universitätsklinikum Hamburg-Eppendorf, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1245107021, G1374194149, G2375902127, SFB 1328: Adeninnukleotide in Immunität und Entzündung, G4201645080, G491379599, G6419202740, Mechanisms of gut epithelial DUOX-mediated intestinal homeostasis, G8107261377
OpenAlex ID: W3212866280
FWCI: 5.756
Cites: 47
Cited by: 61
Related to: 10