Work

Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance

Year: 2021

Type: review

Abstract: century. However, the growing understanding of bacterial pathogenesis and cell-to-cell communication has revealed many potential strategies for the discovery of drugs that can be used for the treatment of bacterial infections. Interfering with bacterial virulence and/or quorum sensing could be a particularly interesting approach, because it is believed to exert less selective pressure on the bacterial resistance than with traditional strategies, geared toward killing bacteria or preventing their growth. Here, we discuss the mechanism of bacterial virulence, presenting promising strategies and recently synthesized heterocyclic compounds to combat future bacterial infections.

Source: RSC Advances

DOI: 10.1039/d1ra06238g

Authors: Rehab H. Abd El-Aleam, Riham F. George, Hanan H. Georgey, Hamdy M. Abdel-Rahman

Institutions: Modern University for Information and Technology, Cairo University, Egyptian Chinese University, Nahda University, Assiut University

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042