[原著］Physicochemical Properties of Human Fibrinogen-Cationic Detergent Complex
Year: 1983
Type: article
Abstract: Sedimentation coefficient, S^0_<20,w> of human fibrinogen-stearyltrimethylammonium chloride, FG-STA(C1), was dependent on pH and the values were found to be 14.3 and 7.2 s at pH 5.8 and 3.8, respectively. Circular dichroism spectra of FG-STA(C1) showed the presence of $ \alpha $-helix (from a double minimum) at between pH 5.8 and 3.8. The molar ellipticity at 222nm were calibrated to be $-10,025 \pm 450$ and $-13,000 \pm 600$ degree・ cm^3・decimole^<-1> at pH 5.8 and 3.8, respectively. It can be suggested that STA-C1 bound to fibrinogen alter the surface character of the protein. Action of STA-C1 is not to denature fibrinogen, but to maintain the conformational structure of the protein.
Authors: Fumihide Inoue, Fukuichi Nakada
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W394876573