Year: 1986
Type: article
Study design: Observational Study
Abstract: Carcinoembryonic antigen (CEA) values (Dinabot-kit) were measured in proven 177 patients with colorectal cancer preoperatively, and at routine intervals following operation.The assay was positive in 39.1% with stage I • II, 65.9% with III • IV and 85.7% with V. Elevated CEA levels were noted in those who had infiltation of cancer cells extending through the proper muscle layer.In 79.2% of curative resections CEA levels returned to normal within one month, but the titers remained elevated in 73.3% of palliative resections.Among 26 patients with recurrent disease, 16 had a hepatic metastasis showing a previous or simultaneous CEA rise, whereas 10 had a local recurrence with a slow rise or normal.In addition, a quantitative study of CEA in extracts of 87 tumors was made in order to assess the influential factors on the level of circulating CEA.There was no significant difference between the CEA contents of the tumor and its level of circulating CEA.The level of circulating CEA might be contributable to the spreading cancer cells rather than the tumor containing CEA.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W401250866