Year: 1994
Type: article
Abstract: 〟ど血ゐJc勧化肋gぬ一札ノ御〃，∫cビれ飢〟J〃血〟rgカr丘岬ビ′J椚e〃ぬJ血j血J，肋仲d∫αれ 舟郁肌n袖∽仰明り厘血叩印画両肌α肋山川血両呵 Ag′血J山rgd〃dVどfe′血り・〟どdノcJ〃g，伽J揖ro，〃0比df れノ叩β〃 Rccじivud】ヱJuly1994／AcceplCd 220ctober1994 Key words＝Babesia microti，nudemice′⊂D4▲Tcells′PrlmaryinfセCtion， gammainterferon， At ‡STRACT Therole ofT eells for the resolution ofacute prlmaryinfection with Bab mtcrotiwasinvestigatedin thepresentstudy・BAL8／emiceexhjbi【ed apeak ParaSitemia ofapproximately40％of parasitemia and subsequentlyrecovered naturallyEromtheirprlmaryinfection・Nude mi⊂e，however，COuldnotresoIve Primaryinfection and developed persistent highparasitemia・Micedepletedo( CD4＋Tcellswithmonoclonalantibody(mAb)hadhighparasitemiaandfai1ed to COntrOltheinfe⊂tion・HoweverldepletionofCD4＋Tcellsoneweekafterinfection did not affe⊂t the course ofinfection・Depletion of CD8十T cells showed no apparent effe⊂t On the course ofinfection・HighconcentrationofIFN- †WaS demonstratedintheculturesupernatantofspleencells fromuntreatedandanti-CD8mAbtreatedmice′ but not fromanti-CD4mAbtreatedmi亡e．Mieetreated WithantiT工FN- †mAb showedhigherpeakparasitemia andremainedabovelO％ Ofparas汗emiauntildays26a［terinEectjon・Theseresult55ugge5rfhatCD4＋Tcel15 PlayanessentialroleintheresolutionofB・mjcrotiacuteprlmaryinfectionand thatIFN-YPrOducedbyCD4＋Tcellsispartiallyresponsible forcontrolofearly S【ageof acuteinfectionwithβ■血亡rロfl■．
Authors: Ikuo Igarashi, Seiji Waki, Mamoru Ito, Yoshitaka Omata, Atsushi Saito, Naoyoshi Suzuki, 郁男 五十嵐
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W405934740