Breath analysis using electronic nose and gas chromatography-mass spectrometry: A pilot study on bronchial infections in bronchiectasis
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND AIMS: In this work, breath samples from clinically stable bronchiectasis patients with and without bronchial infections by Pseudomonas Aeruginosa- PA) were collected and chemically analysed to determine if they have clinical value in the monitoring of these patients. MATERIALS AND METHODS: A cohort was recruited inviting bronchiectasis patients (25) and controls (9). Among the former group, 12 members were suffering PA infection. Breath samples were collected in Tedlar bags and analyzed by e-nose and Gas Chromatography-Mass Spectrometry (GC-MS). The obtained data were analyzed by chemometric methods to determine their discriminant power in regards to their health condition. Results were evaluated with blind samples. RESULTS: : 84-100%) on external validation and the results were confirmed by permutation tests. The discrimination analysis by GC-MS provided good results but did not reach proper statistical significance after a permutation test. CONCLUSIONS: Breath sample analysis by electronic nose followed by proper predictive models successfully differentiated between control, Bronchiectasis and Bronchiectasis PA samples.
Source: Clinica Chimica Acta
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,200
Funders: Centres de Recerca de Catalunya, Fundació Catalana de Pneumologia, European Commission, Generalitat de Catalunya, Federación Española de Enfermedades Raras, Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Universitat de Barcelona, Sociedad Española de Neumología y Cirugía Torácica, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Institute for Bioengineering of Catalonia, Societat Catalana de Pneumologia, Instituto de Salud Carlos III, Departament d'Universitats, Recerca i Societat de la Informació, Institute of BioMed-IT, Energy-IT and Smart-IT Technology (Best), Yonsei University, European Social Fund, H2020 Marie Skłodowska-Curie Actions, HORIZON EUROPE Marie Sklodowska-Curie Actions
Awards: G1570909655, G1781132985, Proyecto PRINCE; Predictores Inmunológicos de Infección Bronquial en Enfermedades Respiratorias Crónicas, G3288897321, Postdoctoral Programme in Bioengineering Excellence Scientific Training, G4087094602, G434337789, G4754130158, Postdoctoral Programme in Bioengineering Excellence Scientific Training, G5024581269, G554876795, G7355274407, G7358480839, G7473301749, G8764575617, G884562473
OpenAlex ID: W4200000646