Year: 2021
Type: article
Study design: Case Report
Abstract: A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.
Source: Frontiers in Immunology
Authors: Kevin M. Vannella, Cihan Oguz, Sydney R. Stein, Stefania Pittaluga, Esra Dikoglu, Arjun Kanwal, Sabrina C. Ramelli, Thomas Briese, Ling Su, Xiaolin Wu, Marcos J. Ramos-Benitez, Luis J. Perez-Valencia, Ashley Babyak, Nu Ri Cha, Joon-Yong Chung, Kris Ylaya, Ronson J. Madathil, Kapil K. Saharia, Thomas M. Scalea, Quincy K. Tran, Daniel L. Herr, David E. Kleiner, Stephen M. Hewitt, Luigi D. Notarangelo, Alison Grazioli, Daniel S. Chertow
Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institutes of Health Clinical Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), National Cancer Institute, Center for Cancer Research, Westchester Medical Center, Columbia University, National Institute of General Medical Sciences, University of Maryland, Baltimore, University of Maryland Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4200005182