Work

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

Year: 2021

Type: article

Abstract: A reservoir of latently HIV-1-infected cells persists in the presence of combination antiretroviral therapy (cART), representing a major obstacle for viral eradication. Reactivation of the latent HIV-1 provirus is part of curative strategies which aim to promote clearance of the infected cells.

Source: mBio

DOI: 10.1128/mbio.02980-21

Authors: Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi

Institutions: Erasmus MC, Tehran University of Medical Sciences, Alexander Fleming Biomedical Sciences Research Center

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Aids Fonds, European Commission, ZonMw, FP7 Ideas: European Research Council

Awards: G3207356259, G59611650, G6119232506, G7546946110, G8440449467, G896728979, G966257856

OpenAlex ID: W4200200743

FWCI: 0.702

Cites: 107

Cited by: 14

Related to: 10