Work

Suppression of MYC transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses

Year: 2021

Type: article

Abstract: Plants tailor immune responses to defend against pathogens with different lifestyles. In this process, antagonism between the immune hormones salicylic acid (SA) and jasmonic acid (JA) optimizes transcriptional signatures specifically to the attacker encountered. Antagonism is controlled by the transcription cofactor NPR1. The indispensable role of NPR1 in activating SA-responsive genes is well understood, but how it functions as a repressor of JA-responsive genes remains unclear. Here, we demonstrate that SA-induced NPR1 is recruited to JA-responsive promoter regions that are co-occupied by a JA-induced transcription complex consisting of the MYC2 activator and MED25 Mediator subunit. In the presence of SA, NPR1 physically associates with JA-induced MYC2 and inhibits transcriptional activation by disrupting its interaction with MED25. Importantly, NPR1-mediated inhibition of MYC2 is a major immune mechanism for suppressing pathogen virulence. Thus, NPR1 orchestrates the immune transcriptome not only by activating SA-responsive genes but also by acting as a corepressor of JA-responsive MYC2.

Source: Cell Reports

DOI: 10.1016/j.celrep.2021.110125

Authors: Mika Nomoto, Michael J. Skelly, Tomotaka Itaya, Tsuyoshi Mori, Takamasa Suzuki, Tomonao Matsushita, Mutsutomo Tokizawa, Keiko Kuwata, Hitoshi Mori, Yoshiharu Y. Yamamoto, Tetsuya Higashiyama, Hironaka Tsukagoshi, Steven H. Spoel, Yasuomi Tada

Institutions: Center for Gene Research, Nagoya University, Nagoya University, University of Edinburgh, Chubu University, Japan Science and Technology Agency, Kyoto University, Gifu University, Institute of Transformative Bio-Molecules, Meijo University

Language: English

Topic: Plant-Microbe Interactions and Immunity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,200

Funders: Royal Society, European Commission, Ministry of Education, Culture, Sports, Science and Technology, University of Tsukuba, Directorate for Biological Sciences, Glenn Research Center, Biotechnology and Biological Sciences Research Council, European Research Council, Japan Society for the Promotion of Science, Japan Science and Technology Agency, Horizon 2020, Division of Graduate Education, Exploratory Research for Advanced Technology, H2020 European Research Council

Awards: Cellular Functions of Proteasome-Associated Ubiquitin Ligase Activity, G2042872135, G283955672, G3070149801, G3261984635, G3484496627, G3719283167, Licensing Transcription Activator Activity with Ubiquitin Time Clocks, Proteasome-Mediated Gene Expression in Plant Immunity, G434337789, G5588472649, G6107708663, G6232132746, Elucidation of the signaling network controlling the crosstalk between plant immunity and environmental response, G7392882631, G7550966680, G948490393

OpenAlex ID: W4200212302

FWCI: 11.19

Cites: 89

Cited by: 122

Related to: 10