The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance
Year: 2021
Type: article
Abstract: SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unclear. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino acid deletion in the N-terminal domain of the Lambda spike protein, is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection. Although this mutation generates a nascent N-linked glycosylation site, the additional N-linked glycan is dispensable for the virological property conferred by this mutation. Since the Lambda variant has dominantly spread according to the increasing frequency of the isolates harboring the RSYLTPGD246-253N mutation, our data suggest that the RSYLTPGD246-253N mutation is closely associated with the substantial spread of the Lambda variant in South America.
Source: Cell Reports
Authors: Izumi Kimura, Yusuke Kosugi, Jiaqi Wu, Jiri Zahradnik, Daichi Yamasoba, Erika P. Butlertanaka, Yuri L. Tanaka, Keiya Uriu, Yafei Liu, Nanami Morizako, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kenzo Tokunaga, Takamasa Ueno, Akifumi Takaori-Kondo, Gideon Schreiber, Hisashi Arase, Chihiro Motozono, Akatsuki Saito, So Nakagawa, Kei Sato
Institutions: Institute of Medical Science, The University of Tokyo, The University of Tokyo, Kyoto University, Tokai University, Japan Science and Technology Agency, Weizmann Institute of Science, Kobe University, University of Miyazaki, Research Institute for Microbial Diseases, The University of Osaka, The University of Osaka, National Institute of Infectious Diseases, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto University, Center for Infectious Disease Education and Research, The University of Osaka, National Institute of Genetics
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
Funders: Japan Agency for Medical Research and Development, Tokyo Biochemical Research Foundation, Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care, University of Tokyo, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Ono Medical Research Foundation, Lotte Foundation, Japan Society for the Promotion of Science, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Institute of Genetics, Core Research for Evolutional Science and Technology, Strategic International Collaborative Research Program, Daiichi Sankyo Europe
Awards: G1214713139, Investigation of virus infection dynamics through comprehensive multi-omics approach, G2462527596, Elucidation of the mechanism of severe viral infections, G3038956225, Studies on the regulation of infection and immunity via paired receptors, Multi-omics analysis and comprehensive understanding of viral perturbation of pathogenesis principles, COVID-19 の発症と病態を規定するウイルス要因・変異の同定とその機序の解明, Investigations of the molecular mechanisms by which the host factor MARCH8 shows a broad antiviral spectrum, G4635277790, G4780202819, Immune regulation by sensing endogenous lipid composition changes via inhibitory C-type lectin receptor, HIV-1産生の不均一性を規定する原理の解明, G6985934550, G7943498302, G8001346496, HIV-1感染における内因性免疫と獲得免疫の相反原理の解明, 新型コロナウイルス感染症 COVID19の病態メカニズム解明と反復パンデミックを防止できる治療薬の開発, Elucidation of molecular determinants for species specificity of flaviviruses, G875571569, G875881984, G8947971140
OpenAlex ID: W4200212523