Deoxynivalenol and Deepoxy-Deoxynivalenol- Induced Alterations in Theca Cell Function as a Major Cause of Infertility in Dairy Cows
Year: 2021
Type: article
Abstract: activate MAPKs [7].In ruminant species, ruminal microorganisms are able to detoxify DON by converting it to the DOM-1, however despite this biochemical degradation DON-associated subclinical health problems are still occurring in dairy cows [8].Nevertheless, the impact of DON and DOM-1 on reproductive system has not been well explored.This study for the first time investigated the effect of mycotoxins on ovarian theca cell function.Although theca cells consist major part of the follicular structure, their role in follicular function has not well studied, however there is no doubt about their contribution in coordinating some signaling networks between pituitary gland, oocyte, granulosa cells and endothelial cells within the ovary.They have receptor for LH and produce androgens that can be converted to estrogens by granulosa cells, thus any alteration in the normal physiologic function of these cells can have significant impact on follicular development and ovulation process resulting in infertility [9].Thus, the objective of the present study was to shed light on the mechanism of action of DON and DOM-1 in bovine theca cells by their effects in the phospho-proteome alterations.Therefore, we used mass spectrometry approach, to evaluate the intracellular pathways of bovine theca cells activated following exposure to the sub-toxic doses of mycotoxins-DON and DOM-1.
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4200215724