Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy
Year: 2021
Type: article
Study design: Case Report
Abstract: Transient prothrombotic disorders caused by plateletactivating antibodies against platelet factor 4 (PF4) include heparin-induced thrombocytopenia (HIT), spontaneous HIT syndrome,1 and, most recently, vaccine-induced immune thrombotic thrombocytopenia (VITT).2 Here, we identified prothrombotic, platelet-activating anti-PF4 antibodies, not associated with heparin treatment, in a patient with monoclonal gammopathy that resulted in a chronic hypercoagulability state.
Source: Haematologica
Institutions: Universitätsmedizin Greifswald, University Medical Center Hamburg-Eppendorf, Royal College of Surgeons in Ireland, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Université de Tours, Centre Hospitalier Universitaire de Tours, McMaster University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,157
OpenAlex ID: W4200215914