Work

Type 3 Diabetes? Evaluation of the Noradrenergic System in Diabetic Rats by Underexpression of Tyrosine Hydroxylase in the Central Nervous System

Year: 2021

Type: article

Abstract: Diabetes mellitus (DM) is a chronic inflammatory state that leads to potentially degenerative changes in brain metabolism. Sustained pictures of hypoinsulinemia trigger phosphorylation of the tau protein and production of amyloid plaques, forming senile plaques and neurofibrillary tangles in brain tissue. Diabetic patients have a higher incidence of cognitive impairment and a higher risk of developing Alzheimer's Disease (AD), the most common type of dementia characterized by chronic neurodegeneration involving early synaptotoxicity, suggesting critical links between DM and AD, currently characterized as Type 3 Diabetes.

Source: International Journal of Diabetes and Clinical Research

DOI: 10.23937/2377-3634/1410152

Authors: Klockner Géssica De Mattos Diosti, Lovato Fernanda Christo, Rebouças Rebeca Loureiro, Langer Laura Ingrid Volkweis, Hoegen Ingrid Oliveira, Ronkoski Maria Luiza, Carvalhal Stephanie Rubianne Silva, Collaço Luiz Martins, Marques Camila, Kubrusly Luiz Fernando

Institutions: Faculdade Evangélica do Paraná, Universidade Federal do Paraná, Hospital Universitário Evangélico de Curitiba

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4200217294

FWCI: 0.091

Cites: 12

Cited by: 1

Related to: 10