Effect of thyroid dysfunction on hematological profiles at Menelik II Referral Hospital, Addis Ababa, Ethiopia
Year: 2021
Type: preprint
Study design: Observational Study
Abstract: Background Thyroid hormones have a crucial role in the metabolism, production, and proliferation of blood cells. So the current study aimed to assess the hematological profile of patients with thyroid dysfunction. Methods A comparative prospective study was conducted from June to September 2021; on a total of 360 participants (120 health groups and 240 patients with thyroid dysfunction. 10 ml of venous blood samples were collected and separated into two test tubes (in the SST tube used for measurement of TSH, T3, and T4, and sample in the EDTA tubes was used for CBC analysis). The analysis was done by using SPPS software. Finally, the result was interpreted by using chi-square, Pearson's correlation, and multivariate logistic regression. The level of statistical significance was set at a 95% confidence and P-value is less than 0.05 was considered clinically significant. Results Out of 360 study participants (120 (33.33%) hypothyroidism, 120 (33.33%) hyperthyroidism, and 120 (33.33%) healthy controls); 195 (54.2%) were female, 150 (41.7%) were in the age range of 25-44 years. The finding indicated a statistically significant decrease in RBC, Hgb, HCT, MCV, PLT, MCH, MCHC, MPV, and a significantly increased valve in RDW, WBC, and NEU% in both types of thyroid dysfunction compared to control groups (p-value <0.05). Finding of MON%, EOS% and BAS% did not show significant differences between the groups (p-value >0.05). Conclusion The finding showed that thyroid dysfunction has a significant effect on RBCs, Hgb, HCT, MCV MCHC, MCH, WBC, neutrophils, PLT count, and MPV findings (p<0.05). But no show significant effect on monocyte, eosinophil and basophils (p-value > 0.05).
Source: Research Square
Authors: Haymanot Tewabe, Assaye Mitiku, Abtie Abebaw
Institutions: Dilla University, Debre Markos University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4200224701