Modeling the number of people infected with SARS-COV-2 from wastewater viral load in Northwest Spain
Year: 2021
Type: article
Abstract: The quantification of the SARS-CoV-2 RNA load in wastewater has emerged as a useful tool to monitor COVID–19 outbreaks in the community. This approach was implemented in the metropolitan area of A Coruña (NW Spain), where wastewater from a treatment plant was analyzed to track the epidemic dynamics in a population of 369,098 inhabitants. Viral load detected in the wastewater and the epidemiological data from A Coruña health system served as main sources for statistical models developing. Regression models described here allowed us to estimate the number of infected people (R2 = 0.9), including symptomatic and asymptomatic individuals. These models have helped to understand the real magnitude of the epidemic in a population at any given time and have been used as an effective early warning tool for predicting outbreaks in A Coruña municipality. The methodology of the present work could be used to develop a similar wastewater-based epidemiological model to track the evolution of the COVID–19 epidemic anywhere in the world where centralized water-based sanitation systems exist.
Authors: Juan A. Vallejo, Noelia Trigo-Tasende, Soraya Rumbo-Feal, Kelly Conde-Pérez, Ángel López-Oriona, Inés Barbeito, Manuel Vaamonde, Javier Tarrío-Saavedra, Rubén Reif, Susana Ladra, Bruno K. Rodiño-Janeiro, Mohammed Nasser-Ali, Ángeles Cid, María Veiga, Antón Acevedo, Carlos Lamora, Germán Bou, Ricardo Cao, Margarita Poza
Institutions: Universidade da Coruña, Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña, Centro de Investigación Biomédica en Red Enfermedades Infecciosas, Universidade de Santiago de Compostela, Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Instituto de Investigación Sanitaria de Santiago, Xunta de Galicia, Instituto tecnológico de Matemática Industrial, Universidade de Vigo
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,400
Funders: European Commission, Ministerio de Economía y Competitividad, Ministerio de Ciencia e Innovación, Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España, Axencia Galega de Innovación, Xunta de Galicia, Universidade da Coruña, HORIZON EUROPE Framework Programme, Instituto de Salud Carlos III, European Regional Development Fund, Servicio Gallego de Salud
Awards: FARMACOMICROBIÓMICA Y MEDICINA PERSONALIZADA EN LA TERAPIA DEL CÁNCER COLORECTAL, G1216440187, G12405879, G1300322159, G1496055848, G1648409450, G1694499074, G1775204680, G183999818, G1933851018, G2233490251, G2549797331, G2567209517, G2864423264, G295869355, G2964649255, G3145880764, G3199046289, G3208361688, G3694284866, G3876637791, European Virus Archive GLOBAL, G4193446334, G4251573389, G4259836820, G4333900429, G434337789, G4604715668, G4962596009, G5086220675, G5451853434, G5805502524, Evaluación de nuevas estrategias antimicrobianas mediante silenciamiento de ARN vehiculizado en nanocápsulas e inhibidores enzimáticos, G6991245890, G726424357, Desarrollo de una plataforma universal de vacunas bacterianas vivas atenuadas auxótrofas para D-glutamato: prevención y erradicación de infecciones por bacterias multirresistentes, G7929129924, G7994548261, G8398317784, G8692927972
OpenAlex ID: W4200329204