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Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma

Year: 2021
Type: article
Study design: Observational Study
Abstract: The controlling nutritional status (CONUT) score is a simplified nutritional index calculated from serum albumin, total cholesterol, and total lymphocyte count. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with peripheral T-cell lymphoma (PTCL). A multicenter, retrospective cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11; p = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.119, 95% confidence interval 1.021-1.227, p = 0.017). No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI (P for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor for PTCL irrespective of IPI category.
DOI: 10.1080/10428194.2021.2020777
Authors: Nobuhiko Nakamura, Nobuhiro Kanemura, Shin Lee, Kei Fujita, Tetsuji Morishita, Eri Takada, Yuhei Shibata, Senji Kasahara, Hideko Goto, Kenji Fukuno, Takeshi Hara, Toshiki Yamada, Michio Sawada, Hisashi Tsurumi, Masahito Shimizu
Institutions: Gifu University Hospital, Matsunami General Hospital, Kyoto University, Gihoku Kosei Hospital, Gifu Municipal Hospital, Chuno Kosei Hospital, Takayama Red Cross Hospital, Gifu Prefectural General Medical Center, Gifu Red Cross Hospital
Language: English
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4200423989
FWCI: 3.069
Cites: 20
Cited by: 15
Related to: 10