CTCF puts a new twist on UV damage and repair in skin cancer
Year: 2021
Type: editorial
Abstract: Somatic mutations in skin cancers are highly enriched at binding sites for CCCTC-binding factor (CTCF). We have discovered that CTCF binding alters the DNA structure to render it more susceptible to UV damage. Elevated UV damage formation at CTCF binding sites, in conjunction with subsequent repair inhibition, promotes UV mutagenesis.
Source: Molecular & Cellular Oncology
Institutions: Washington State University, Georgia State University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Direct chemical control of the hematopoietic master transcription factor PU.1, Folded state dynamics and hydration in transcriptional regulation, A cellular osmotic pressure sensor, UV damage stimulation by ETS transcription factors in skin cancer, Regulation of DNA Excision Repair in Chromatin, Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancer
OpenAlex ID: W4200440647