Work

Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer

Year: 2021

Type: article

Abstract: To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities.

Source: Bioengineering

DOI: 10.3390/bioengineering9010005

Authors: Maria Fedotova, Maksim Usachev, Ekaterina Bogdanova, Ekaterina Diachkova, Yuriy Vasil’ev, Vladimir Bregadze, Andrey Mironov, Mikhail Grin

Institutions: MIREA - Russian Technological University, Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds, Sechenov University, Federal State University of Education, Kazan State Medical University

Language: English

Topic: Boron Compounds in Chemistry

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,728

Funders: MIREA - Russian Technological University, Russian Foundation for Basic Research, Ministry of Science and Higher Education of the Russian Federation

Award: G5923606180

OpenAlex ID: W4200510262

FWCI: 0.325

Cites: 22

Cited by: 5

Related to: 10