Work

Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

Year: 2021

Type: article

Study design: Observational Study

Abstract: Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the “environmental” mutation TR34/L98H in the cyp51A gene.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofab638

Authors: Silvio Ragozzino, Daniel Goldenberger, Patrick R Wright, Stefan Zimmerli, Konrad Mühlethaler, Dionysios Neofytos, Arnaud Riat, Katia Boggian, Oliver Nolte, Anna Conen, Hans Fankhauser, Peter W Schreiber, Reinhard Zbinden, Frederic Lamoth, Nina Khanna

Institutions: University of Basel, University Hospital of Basel, University of Bern, University Hospital of Bern, University Hospital of Geneva, University of Geneva, Kantonsspital St. Gallen, Zentrum für Labormedizin, Kantonsspital Aarau, University of Zurich, University Hospital Zurich, Centre Hospitalier Universitaire Vaudois

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,465

Funders: Pfizer, Gilead Sciences, Schering-Plough, Novartis Foundation, European Commission, Fondation Leenaards, Centre Hospitalier Universitaire Vaudois, Universität Zürich, Pfizer Foundation, Merck Sharp and Dohme

Awards: G1072915365, G3207356259, G393177772, G5702163051, Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices

OpenAlex ID: W4200527588

FWCI: 0.933

Cites: 15

Cited by: 25

Related to: 10