Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline
Year: 2021
Type: article
Study design: Observational Study
Abstract: Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Results: Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = −0.168/−0.175, indirect effect = −0.081/−0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = −0.037, −0.056, and 0.047, respectively). Conclusions: Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.
Source: Frontiers in Neurology
Institutions: Pusan National University Yangsan Hospital, Pusan National University, Korea University, Samsung Medical Center, Sungkyunkwan University, Gyeongsang National University, Gyeongsang National University Changwon Hospital, Kangwon National University, Chonnam National University, Chonnam National University Hospital, Jeonbuk National University Hospital, Jeonbuk National University, Myongji Hospital, Hanyang University, Pusan National University Hospital, Montreal Neurological Institute and Hospital, McGill University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: Korea Disease Control and Prevention Agency, National Research Foundation, Pusan National University, Ministry of Science, ICT and Future Planning, Korea Health Industry Development Institute, National Research Foundation of Korea, Pusan National University Hospital, Ministry of Science and ICT, South Korea, Institute for Information and Communications Technology Promotion
Awards: G1148046061, G1215950653, G1478288009, G1539597470, G1676546911, G1743971674, G2685699718, G2750025839, G3414274222, G3705877861, G3839290543, G4351754709, G4553726846, G4643994530, G475471570, G476240310, G4782972199, G506709279, G5572715927, G5799620071, G5930330670, G6632395612, G6632597423, G6651501077, G7193746857, G7472513699, G7748090981, G7922504281, G8212785192, G8218097239, G8787226706
OpenAlex ID: W4200548949