Work

CAR T cell therapy in solid tumors: A review of current clinical trials

Year: 2021

Type: review

Abstract: Chimeric antigen receptor (CAR) T cell therapy has made tremendous strides in the arena of hematological malignancies with approved therapies in certain leukemias, lymphomas, and recently myeloma with overall highly favorable response rates. While numerous clinical studies are still ongoing for hematological malignancies, research is developing to translate the feasibility of CAR T therapy in solid organ malignancies. Unfortunately, the majority of diagnosed cancers are primarily solid tumors. Thus, a highly unmet clinical need for further research and development exists in this field. This review article highlights currently active clinical trials and a few pertinent preclinical studies involving CAR T cell therapy in solid tumors while briefly discussing study outcomes and potential key targets that may allow for the feasibility of this therapy option. Finally, we mention critical challenges existing in the solid tumor environment and discuss developing strategies that may potentially overcome the existing barriers to CAR T cell progress in solid tumors.

Source: eJHaem

DOI: 10.1002/jha2.356

Authors: Urvi Patel, John Abernathy, Bipin N Savani, Olalekan Oluwole, Salyka Sengsayadeth, Bhagirathbhai Dholaria

Institutions: University of Tennessee Health Science Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,250