Human papillomavirus vaccine effectiveness by age at first vaccination among Japanese women
Year: 2022
Type: article
Study design: Observational Study
Abstract: In Japan, the National Immunization Program against human papillomavirus (HPV) targets girls aged 12-16 years, and catch-up vaccination is recommended for young women up to age 26 years. Because HPV infection rates increase soon after sexual debut, we evaluated HPV vaccine effectiveness by age at first vaccination. Along with vaccination history, HPV genotyping results from 5795 women younger than 40 years diagnosed with cervical intraepithelial neoplasia grade 2-3 (CIN2-3), adenocarcinoma in situ (AIS), or invasive cervical cancer were analyzed. The attribution of vaccine-targeted types HPV16 or HPV18 to CIN2-3/AIS was 47.0% for unvaccinated women (n = 4297), but 0.0%, 13.0%, 35.7%, and 39.6% for women vaccinated at ages 12-15 years (n = 36), 16-18 years (n = 23), 19-22 years (n = 14), and older than 22 years (n = 91), respectively, indicating the greater effectiveness of HPV vaccination among those initiating vaccination at age 18 years or younger (P < .001). This finding was supported by age at first sexual intercourse; among women with CIN2-3/AIS, only 9.2% were sexually active by age 14 years, but the percentage quickly increased to 47.2% by age 16 and 77.1% by age 18. Additionally, the HPV16/18 prevalence in CIN2-3/AIS was 0.0%, 12.5%, and 40.0% for women vaccinated before (n = 16), within 3 years (n = 8), and more than 3 years after (n = 15) first intercourse, respectively (P = .004). In conclusion, our data appear to support routine HPV vaccination for girls aged 12-14 years and catch-up vaccination for adolescents aged 18 years and younger in Japan.
Source: Cancer Science
DOI: 10.1111/cas.15270
Authors: Mamiko Onuki, Kasumi Yamamoto, Hideaki Yahata, Hiroyuki Kanao, Harushige Yokota, Hisamori Kato, Kumi Shimamoto, Kazuhiro Takehara, Shoji Kamiura, Naotake Tsuda, Yuji Takei, Shogo Shigeta, Noriomi Matsumura, Hiroyuki Yoshida, Takeshi Motohara, Hidemichi Watari, Keiichiro Nakamura, Akihiko Ueda, Nobutaka Tasaka, Mitsuya Ishikawa, Yasuyuki Hirashima, Wataru Kudaka, Ayumi Taguchi, Takashi Iwata, Fumiaki Takahashi, Iwao Kukimoto, Hiroyuki Yoshikawa, Nobuo Yaegashi, Koji Matsumoto, for the MINT Study Group
Institutions: SHOWA Medical University, Hyogo Prefectural Cancer Center, Kyushu University, The Cancer Institute Hospital, Saitama Cancer Center, Kanagawa Cancer Center, National Hospital Organization Kyushu Cancer Center, Shikoku Cancer Center, Osaka International Cancer Institute, Kurume University, Jichi Medical University, Jichi Medical University Hospital, Tohoku University, Kindai University, Saitama International Medical Center, Saitama Medical University, Kumamoto University, Hokkaido University, Okayama University, Kyoto University, University of Tsukuba, National Cancer Center Hospital, Shizuoka Cancer Center, University of the Ryukyus, The University of Tokyo, Keio University, Iwate Medical University, National Institute of Infectious Diseases
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,600
OpenAlex ID: W4205230741