Work

RNA gradients: Shapers of 3D genome architecture

Year: 2022

Type: review

Abstract: A growing body of evidence points to a role of nuclear RNAs (nucRNAs) in shaping the three-dimensional (3D) architecture of the genome within the nucleus of a eukaryotic cell. nucRNAs are non-homogeneously distributed within the nucleus where they can form global and local gradients that might contribute to instructing the formation and coordinating the function of different types of 3D genome structures. In this article, we highlight the available literature supporting a role of nucRNAs as 3D genome shapers and propose that nucRNA gradients are key mediators of genome structure and function.

Source: Current Opinion in Cell Biology

DOI: 10.1016/j.ceb.2021.12.001

Authors: Britta A.M. Bouwman, Nicola Crosetto, Magda Bienko

Institutions: Science for Life Laboratory, Karolinska Institutet

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,530

Funders: European Commission, Horizon 2020 Framework Programme, European Research Council, H2020 European Research Council