Year: 2022
Type: review
Abstract: KRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due to its impact on the modulation of cancer cell activities, which can dictate the success of tumor progression. Here, we aimed to clarify the pro- and anti-inflammatory role of KRAS mutations over the TME, detailing the context and the signaling pathways involved. In this review, we expect to open new avenues for investigating the potential of KRAS mutations on inflammatory TME modulation, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer.
Source: Cells
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,303
Awards: The role of Bcl-2 protein family and Beclin-1 in KRAS-mediated regulation of apoptosis/autophagy using yeast and colorectal cancer as models, CENTRO DE BIOLOGIA MOLECULAR E AMBIENTAL, G7057198478, Combate aos cancros metastáticos: o palco é do ruténio, Uncover the role of KRAS/galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages: therapeutic implications
OpenAlex ID: W4210550996