Year: 2022
Type: article
Abstract: Synthesis of novel 225Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl2 with 0.2 mCi 225Ac furnished highly stable 225Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the 225Ac decay chain. 225Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.
Source: Advances in Nanoparticles
Authors: Davut Cakici, Benan Kilbas
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4211211331