05 / Plasma Concentrations of N-Terminal Pro-B-Type Natriuretic Peptide after caesarean section under spinal anaesthesia
Year: 2018
Type: other
Abstract: Background and Goal of Study:N-terminal pro-B-type natriuretic peptide (NT-pro BNP) is a powerful predictor of cardiovascular outcome in many circumstances. Plasma concentrations of NT-pro BNP have been shown to reflect cardiac dysfunction and volume overload. During spinal anaesthesia for caesarean section, hemodynamic changes and the effects of various treatment regimens on NT-pro BNP are not studied. The aim of this study was to assess serum levels of NT-pro BNP after caesarean delivery under spinal anaesthesia.Materials and Methods:We conduct a prospective observational study at a tertiary level hospital over a period of 2 months. The study was approved by the hospital ethics committee. After receipt of informed consent, healthy pregnant women proposed for caesarean sections under spinal anaesthesia were included. NT pro BNP level were measured at 2, 8 and 24 hours after delivery.Results:One hundred and eighty-nine patients were enrolled in this study. The mean age was 32.4u00b15,7years. The mean gestational age was 36.48 u00b11.55 weeks of gestation. Fifty-six parturients (29.6%) showed a significant increase in NT pro BNP level in postpartum period.Two of these patients had a history of treated mitral valvular disease. The mean value of NTpro BNP was 341.7 u00b1 571.5pg /ml at H2, 571.8u00b11591.18 pg/ ml at H8 and 388 u00b11941.15 pg/ ml at H24.The NTpro BNP elevation was associated with a Body Mass Index greater than 30 kg/m2, ephedrine dose more than 30mg and oxytocin dose higher than 25UI, preeclampsia and hemodynamic instability.Echocardiography performed subsequently in positive patients showed hypertrophic cardiomyopathy in all preeclamptic patients and was normal in the remaining patients.Conclusion(s):In our study, a significant increase in serum levels of NT pro BNP was observed in 29.6% of study patients. These results may reflect myocardium damage during cesarean delivery due to hemodynamic instability especially in presence of preeclampsia, which suggest that this peptide acts as a biomarker for high risk pregnancies.
Authors: Hosni Khouadja, Hosni ['ferhi']
Institution: Hôpital Farhat Hached
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4213036191