Work

Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Year: 2022

Type: article

Abstract: This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N -(5-cyano-3-methyl-1-phenyl-1 H -pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 precursors. The action of chlorosulfonyl isocyanate (CSI) with aminopyrazolo[3,4- d ]pyrimidines 2 was found to produce triazolopyrimidinones 5 . The MTT test that quantifies mitochondrial reductive function demonstrated that in both cell lines tested (PE/CA-PJ41 and HePG2 cells), the benzamide compounds 4 are moderately toxic with PE/CA-PJ41 cells and more sensitive than HePG2 cells.

Source: Heterocyclic Communications

DOI: 10.1515/hc-2022-0001

Authors: Soumaya Bellili, Nicholas J. Coltman, Nikolas J. Hodges, Fatma Allouche

Institutions: University of Sfax, University of Birmingham

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,580