Year: 2022
Type: article
Abstract: BACKGROUND: Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19. METHODS: This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up. RESULTS: We included 905 patients. Their median age was 51 (IQR 45-65), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6-39) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5-21.8%) and after 9 months in 16.0% (95% confidence interval: 13.7-18.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582-0.737). CONCLUSION: The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.
Source: Cephalalgia
Authors: David Garcia-Azorin, Almudena Layos-Romero, Jesús Porta-Etessam, Javier A Membrilla, Edoardo Caronna, Alicia Gonzalez-Martinez, Álvaro Sierra Mencia, Tomás Segura, Nuria Gonzalez-García, Javier Díaz-de-Terán, Victor J Gallardo, Ana Beatriz Gago-Veiga, Alejandro Ballvé, Javier Trigo López, María Sastre-Real, Arnau Llauradó, Ana Cornejo, Íñigo de Lorenzo, Ángel Guerrero-Peral, Patricia Pozo-Rosich
Institutions: Hospital Clínico Universitario de Valladolid, Hospital General Universitario de Albacete, Complejo Hospitalario Universitario de Albacete, Universidad Complutense de Madrid, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Universitat Autònoma de Barcelona, Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Hospital Universitario de La Princesa, Universidad de Valladolid
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4213242575