Work

Influence of interaction of cerebral fluids on ventricular deformation: A mathematical approach

Year: 2022

Type: article

Abstract: This paper describes the effects of the interaction of cerebral fluids (arterial, capillary and venous blood, cerebrospinal fluid) on ventricular wall displacement and periventricular pressure using a mathematical multiphase poroelasticity model for the cerebral parenchyma. The interaction of cerebral fluids is given by a set of four numerical coefficients. A multiple linear regression with interaction is constructed that allows us to quantify the effect of these coefficients on the average ventricular wall displacement. The prevailing influence of an arterial-liquor component was observed. The sets of coefficients associated with such pathological conditions were found: normal pressure hydrocephalus, intracranial hypertension, and replacement ventriculomegaly under a prolonged hypoperfusion.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0264395

Authors: Galina Valova, Olga Bogomyakova, Andrey Tulupov, Alexander Cherevko

Institutions: Siberian Branch of the Russian Academy of Sciences, Lavrentyev Institute of Hydrodynamics, International Tomography Center

Language: English

Topic: Cerebrospinal fluid and hydrocephalus

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,805