Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces
Year: 2022
Type: article
Abstract: The Utah array powers cutting-edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in the last three decades. Here, advanced dual-side lithographic microfabrication processes is exploited to demonstrate a 1024-channel penetrating silicon microneedle array (SiMNA) that is scalable in its recording capabilities and cortical coverage and is suitable for clinical translation. The SiMNA is the first penetrating microneedle array with a flexible backing that affords compliancy to brain movements. In addition, the SiMNA is optically transparent permitting simultaneous optical and electrophysiological interrogation of neuronal activity. The SiMNA is used to demonstrate reliable recordings of spontaneous and evoked field potentials and of single unit activity in chronically implanted mice for up to 196 days in response to optogenetic and to whisker air-puff stimuli. Significantly, the 1024-channel SiMNA establishes detailed spatiotemporal mapping of broadband brain activity in rats. This novel scalable and biocompatible SiMNA with its multimodal capability and sensitivity to broadband brain activity will accelerate the progress in fundamental neurophysiological investigations and establishes a new milestone for penetrating and large area coverage microelectrode arrays for brain-machine interfaces.
Source: Advanced Functional Materials
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, American University of Beirut, National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Division of Civil, Mechanical and Manufacturing Innovation, Division of Electrical, Communications and Cyber Systems
Awards: G1311321039, G2007589374, G2164530936, Bringing Light to Functional Mapping in Resective Neurosurgery, SNM: Scalable Nanomanufacturing of Fab Compatible High-Density Nanowire Arrays for High-Throughput Drug Screening, CAREER: High Density Bio-Compatible Electro-Fluidic Neural Interfaces for Mapping the Brain, NNCI: San Diego Nanotechnology Infrastructure (SDNI), MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGING, Center for the Study of the Neural Bases of Language and Learning, Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and Stimulation, High-density microgrid development for human neural interface devices, Specialized Cancer Center Support Grant, G8026919152, Effects of intrinsic and drug-induced neuromodulation on functional brain imaging, Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy
OpenAlex ID: W4214714756