Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines
Year: 2022
Type: preprint
Abstract: The SARS-CoV-2 Omicron variant of concern comprises three sublineages designated BA.1, BA.2, and BA.3, with BA.2 steadily replacing the globally dominant BA.1. We show that the large number of BA.1 and BA.2 spike mutations severely dampen plasma neutralizing activity elicited by infection or seven clinical vaccines, with cross-neutralization of BA.2 being consistently more potent than that of BA.1, independent of the vaccine platform and number of doses. Although mRNA vaccines induced the greatest magnitude of Omicron BA.1 and BA.2 plasma neutralizing activity, administration of a booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1 and BA.2 across all vaccines evaluated. Our data suggest that although BA.1 and BA.2 evade polyclonal neutralizing antibody responses, current vaccine boosting regimens may provide sufficient protection against Omicron-induced disease.
Authors: John E. Bowen, Kaitlin R. Sprouse, Alexandra C. Walls, Ignacio G. Mazzitelli, Jennifer K. Logue, Nicholas M. Franko, Kumail Ahmed, Asefa Shariq, Elisabetta Cameroni, Andrea Gori, Alessandra Bandera, Christine M. Posavad, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Najeeha Talat Iqbal, Davide Corti, Jorge Geffner, Renata Grifantini, Helen Y. Chu, David Veesler
Institutions: University of Washington, Howard Hughes Medical Institute, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Aga Khan University, Vir Biotechnology (Switzerland), University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centre for Multidisciplinary Research in Health Science, Fred Hutch Cancer Center, La Jolla Institute for Immunology, University of California San Diego, Istituto Nazionale Genetica Molecolare
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Howard Hughes Medical Institute, Burroughs Wellcome Fund, Bill and Melinda Gates Foundation, University of Washington, Fast Grants, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases
Awards: G1149586160, G1580077915, G1880986580, G2553103453, G255812968, G276384829, SARS-CoV-2 correlates of protection in a Latino-origin population, G3780234185, G6282704698, G6381443592, G7282994068, G7848094000, G8003535823, G8424743005, G8801929157, G8803165438, G9000259159, G9000260163, G9000264621, G9000344341, G9000346859, Human immune memory to COVID-19, vaccines, and respiratory pathogens, UC San Diego Raising Advancement and Parity for Infectious Disease Researchers (RAPID) Faculty Development Program
OpenAlex ID: W4220708346