Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices
Year: 2022
Type: article
Study design: Observational Study
Abstract: Both the serotonin transporter polymorphism (5-HTTLPR) and the monoamine oxidase A gene (MAOA-uVNTR) are considered genetic contributors for anxiety-related symptomatology and aggressive behavior. Nevertheless, an interaction between these genes and the pre-attentive processing of threatening voices -a biological marker for anxiety-related conditions- has not been assessed yet. Among the entire sample of participants in the study with valid genotyping and electroencephalographic (EEG) data (N = 140), here we show that men with low-activity MAOA-uVNTR, and who were not homozygous for the 5-HTTLPR short allele (s) (n = 11), had significantly larger fearful MMN amplitudes -as driven by significant larger ERPs to fearful stimuli- than men with high-activity MAOA-uVNTR variants (n = 20). This is in contrast with previous studies, where significantly reduced fearful MMN amplitudes, driven by increased ERPs to neutral stimuli, were observed in those homozygous for the 5-HTT s-allele. In conclusion, using genetic, neurophysiological, and behavioral measurements, this study illustrates how the intricate interaction between the 5-HTT and the MAOA-uVNTR variants have an impact on threat processing, and social cognition, in male individuals (n = 62).
Source: Communications Biology
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,490
Awards: Investigation of the Impacts of Histone Methylation Dynamics on Colorectal Cancer Progression and Immunotherapy Responsiveness( III ), A Cross-Culture Moral Developmental Study (Usa, France and Taiwan): Incorporating Neuroimaging, Behavioral Investigation and Artificial Intelligence to Develop Models for Behavior Prediction.( Iv ), Investigation of the Impacts of Histone Methylation Dynamics on Colorectal Cancer Progression and Immunotherapy Responsiveness( Iv ), A Cross-Culture Moral Developmental Study (Usa, France and Taiwan): Incorporating Neuroimaging, Behavioral Investigation and Artificial Intelligence to Develop Models for Behavior Prediction.( III )
OpenAlex ID: W4223563788