New insights into the genetic etiology of Alzheimer’s disease and related dementias
Year: 2022
Type: article
Study design: Observational Study
Abstract: ABSTRACT Alzheimer’s disease (AD) is a severe and incurable neurodegenerative disease, and the failure to find effective treatments suggests that the underlying pathology remains poorly understood. Due to its strong heritability, deciphering the genetic landscape of AD and related dementia (ADD) is a unique opportunity to advance our knowledge. We completed a meta-analysis of genome-wide association studies (39,106 clinically AD-diagnosed cases, 46,828 proxy-ADD cases and 401,577 controls) with the most promising signals followed-up in 25,392 independent AD cases and 276,086 controls. We report 75 risk loci for ADD, including 42 novel ones. Pathway-enrichment analyses confirm the involvement of amyloid/Tau pathways, highlight the role of microglia and its potential interaction with APP metabolism. Numerous genes exhibited differential expression or splicing in AD-related conditions and gene prioritization implies EGFR signaling and TNF-α pathway through LUBAC complex. We also generated a novel polygenic risk score strongly associated with the risk of future dementia or progression from mild cognitive impairment to dementia. In conclusion, by more than doubling the number of loci associated with ADD risk, our study offers new insights into the pathophysiological processes underlying AD and offers additional therapeutic entry-points and tools for translational genomics.
Source: Nature Genetics
Authors: Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C. Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A. Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Ivana Prokic, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo Garcia-Gonzalez, Carla Abdelnour, Emilio Alarcón-Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belén Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Mercè Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Bûrger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Geneviève Chene, Jaeyoon Chung, Michael L. Cuccaro, Ángel Carracedo, Roberta Cecchetti, Laura Cervera-Carles, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A. H. R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma-Gómez, Emanuele Costantini, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean-François Dartigues, Peter Paul de Deyn, Katia de Paiva Lopes, Lot D. de Witte, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Anita DeStefano, Martin Dichgans, Janine Diehl-Schmid, Mónica Diez-Fairen, Paolo Dionigi Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Tagliavini Fabrizio, Sune Fallgaard Nielsen, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández-Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. 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Henderson, Michelle Hernandez, Timothy Hohman, Lawrence S. Honig, Ryan M. Huebinger, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Linda S. Hynan, Laura Ibanez, Gail P. Jarvik, Suman Jayadev, Lee-Way Jin, Kim Johnson, Leigh Johnson, M. Ilyas Kamboh, Anna M. Karydas, Mindy J. Katz, Jeffrey A. Kaye, C. Dirk Keene, Aisha Khaleeq, Ronald Kim, Janice Knebl, Neil W. Kowall, Joel H. Kramer, Pavel P. Kuksa, Frank M. LaFerla, James J. Lah, Eric B. Larson, Chien-Yueh Lee, Edward B. Lee, Alan Lerner, Yuk Yee Leung, James B. Leverenz, Allan I. Levey, Mingyao Li, Andrew P. Lieberman, Richard B. Lipton, Mark Logue, Constantine G. Lyketsos, John Malamon, Douglas Mains, Daniel C. Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Paul Massman, Arjun Masurkar, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Stefan McDonough, Ann C. McKee, Marsel Mesulam, Jesse Mez, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, Edwin S. Monuki, John C. 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Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimon, Jean-François Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustín Ruiz, Alfredo Ramirez, Jean-Charles Lambert
Institutions: Inserm, Université de Lille, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Approches épidémiologiques et moléculaires intégratives visant à améliorer la compréhension des maladies chroniques liées au vieillissement, University of Antwerp, VIB-UAntwerp Center for Molecular Neurology, Institute Born-Bunge, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Cologne, University Hospital Bonn, German Center for Neurodegenerative Diseases, Instituto de Salud Carlos III, Universitat Internacional de Catalunya, Biomedical Research Networking Center on Neurodegenerative Diseases, Fundació ACE, Erasmus MC, University of Oxford, University of Pennsylvania, Cardiff University, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Centre National de Recherche en Génomique Humaine, Universidade Federal do Rio Grande do Norte, University of Eastern Finland, Boston University, Framingham Heart Study, University of Washington, Uppsala University, Stavanger University Hospital, Universidad de Málaga, Universitat Autònoma de Barcelona, Hospital de Sant Pau, University Hospital Mútua de Terrassa, Hospital Universitario Central de Asturias, UNSW Sydney, Centre for Healthy Brain Ageing, Aristotle University of Thessaloniki, Greek Association of Alzheimer's Disease and Related Disorders, Hospital Universitario Virgen de la Arrixaca, Azienda Ospedaliera San Gerardo, University of Milano-Bicocca, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Hospital Universitari de Santa Maria, Instituto de Investigación Biomédica de Lleida, Fundacion Centro De Investigacion De Enfermedades Neurologicas, University of Milan, University of Oslo, Université Paris Cité, Hôpital Broca, Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologie, Fondazione Santa Lucia, Hospital Universitari i Politècnic La Fe, University of Parma, Alexandrovska Hospital, Medical University of Sofia, Columbia University, Vanderbilt University, The University of Texas Health Science Center at Houston, Case Western Reserve University, Centro San Giovanni di Dio Fatebenefratelli, Université de Montpellier, Neuropsychiatrie : Recherche Epidemiologique et Clinique, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Baylor College of Medicine, University of Brescia, University of Turin, Norwegian University of Science and Technology, St Olav's University Hospital, Nottingham Trent University, Universidad de Buenos Aires, LMU Klinikum, Institut für Schlaganfall- und Demenzforschung, Ludwig-Maximilians-Universität München, University of Auckland, Swansea University, Unidad Funcional de Investigación de Enfermedades Crónicas, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Bordeaux Population Health, Centre d'Investigation Clinique Plurithématique de Bordeaux, University of Miami, Universidade de Santiago de Compostela, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago, University of Perugia, Normandie Université, University of Cagliari, Azienda Ospedaliero-Universitaria Cagliari, Radboud University Nijmegen, Radboud University Medical Center, University of Zurich, Hospital Universitario de Valme, University of Bari Aldo Moro, University of Thessaly, University Medical Center Groningen, Icahn School of Medicine at Mount Sinai, Universitätsklinikum Würzburg, Munich Cluster for Systems Neurology, TUM Klinikum, Technical University of Munich, Otto-von-Guericke-Universität Magdeburg, Icelandic Heart Association, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, Indiana University Indianapolis, Fondazione IRCCS Istituto Neurologico Carlo Besta, Herlev Hospital, Gentofte Hospital, University of Kentucky, Texas Tech University, UCL Queen Square Institute of Neurology, University College London, Texas Tech University Health Sciences Center, University of Lisbon, Donauspital, The University of Texas at San Antonio Health Science Center, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Hospital La Paz Institute for Health Research, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Hospital Universitario La Paz, Heidelberg University, Central Institute of Mental Health, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Medical University of Vienna, Karolinska University Hospital, Karolinska Institutet, Stockholm University, University of Cambridge, ETH Zurich, Psychiatrische Universitätsklinik Zürich, University of Iceland, University of Nottingham, University of Cyprus, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Alzheimer Precision Medicine, University of Bonn, University of Southampton, Utrecht University, University Medical Center Utrecht, Brigham Young University, University of Bristol, Imperial College London, University of Helsinki, Helsinki University Hospital, Kuopio University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Universidad de Cantabria, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, Stockholm Gerontology Research Center Foundation, National Institutes of Health, National Institute on Aging, Finnish Institute for Health and Welfare, Charles University, International Clinical Research Center, St. Anne's University Hospital Brno, Osakidetza, Donostiako Unibertsitate Ospitalea, Bangor University, Università Cattolica del Sacro Cuore, MRC Prion Unit, Essen University Hospital, University of Duisburg-Essen, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Consejo Nacional de Investigaciones Científicas y Técnicas, University of Mississippi Medical Center, Institute for Medical Research, Don Carlo Gnocchi Foundation, University of Copenhagen, Lille Neurosciences & Cognition, Instituto de Biomedicina de Valencia, Instituto de Investigación Sanitaria La Fe, Centre National de la Recherche Scientifique, Plateformes Lilloises en Biologie et Santé, Humboldt-Universität zu Berlin, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Centre Hospitalier Universitaire Vaudois, University Hospital Zurich, Stiftung Charité, Rigshospitalet, Maastricht University, Delft University of Technology, Leipzig University, Fonna Hospital Trust, University of Bergen, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Hospital Universitario de Gran Canaria Doctor Negrín, Universitat de Barcelona, National and Kapodistrian University of Athens, University Medical Center Hamburg-Eppendorf, Institut für Medizinische Biometrie, Informatik und Epidemiologie, Oslo University Hospital, Ospedale Vito Fazzi, Hospital Clínico San Carlos, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Centro de Investigación Biomédica en Red, Namsos Hospital, Universitair Ziekenhuis Leuven, KU Leuven, Harvard University, McLean Hospital, Universitätsmedizin Göttingen, University of Aveiro, Harokopio University of Athens, Biogipuzkoa Health Research Institute, Na Homolce Hospital, University of Oulu, King's College London, Queen's Medical Centre, Queen's University Belfast, Wellcome Sanger Institute, St. James's Hospital, Dublin City University, QIMR Berghofer Medical Research Institute, Manchester Academic Health Science Centre, University of Manchester, John Radcliffe Hospital, Hospital Clínico Universitario de Valencia, Hertie Institute for Clinical Brain Research, University of Würzburg, Hospital El Cruce, UK Dementia Research Institute, Hospital Universitario Son Espases, University of the Basque Country, Fundacion CITA Alzheimer, Navarrabiomed, Hospital Universitario de La Princesa, Mécanismes Adaptatifs et Evolution, Institut du Cerveau, Newcastle University, Somerset Partnership NHS Foundation Trust, University Hospital of Wales, Helmholtz Munich, University of Freiburg, Helse Nord-Trøndelag HF, Akershus University Hospital, Innlandet Hospital Trust, Institute for Molecular Medicine Finland, HiLIFE – Elämäntieteiden Instituutti, AbbVie (United States), AstraZeneca (United Kingdom), Biogen (United States), Celgene (United States), Genentech, GlaxoSmithKline (United Kingdom), Merck & Co., Inc., Rahway, NJ, USA (United States), Pfizer (United States), Sanofi (France), Maze (United States), Janssen (Belgium), University of Turku, Varsinais-Suomen Sairaanhoitopiiri, Finnish Red Cross, Hospital District of Helsinki and Uusimaa, Northern Ostrobothnia Hospital District, Tampere University, Pirkanmaa Hospital District, University of Tampere, Pohjois-Savon sairaanhoitopiiri, Central Finland Health Care District, University of Jyväskylä, Business Finland, Bristol-Myers Squibb (United States), Broad Institute, Stanford University, The University of Texas Southwestern Medical Center, The University of Texas at Austin, Johns Hopkins University, University of Michigan, Mayo Clinic in Florida, University of North Texas Health Science Center, Indiana University School of Medicine, University of Wisconsin–Madison, Rush University Medical Center, Banner Sun Health Research Institute, University of Pittsburgh, National Alzheimer's Coordinating Center, Washington University in St. Louis, Northwestern University, VA Puget Sound Health Care System, Mayo Clinic, Swedish Medical Center, University of California, San Francisco, University of California San Diego, Duke University, University of Kansas, University of Kansas Medical Center, University of South Florida, USF Health Byrd Alzheimer's Institute, Fred Hutch Cancer Center, Bruce W. Carter VA Medical Center, University of North Carolina at Chapel Hill, University of California, Los Angeles, University of Southern California, Wake Forest University Health Sciences, Wake Forest University, University of California, Irvine, Columbia University Irving Medical Center, University of California, Davis, Mount Sinai Medical Center, University of Alabama at Birmingham, New York University, Massachusetts General Hospital, Emory University, Children's Hospital of Philadelphia, Brigham and Women's Hospital, Stanford Medicine, Vanderbilt University Medical Center, Translational Genomics Research Institute, Albert Einstein College of Medicine, Oregon Health & Science University, Portland VA Medical Center, VA Portland Health Care System, Kaiser Permanente Washington Health Research Institute, Cleveland Clinic, Lou Ruvo Brain Institute, VA Boston Healthcare System, Texas A&M University, University of Colorado Anschutz, Texas Christian University, University of Toronto, Yale University, Renaissance Computing Institute, University of Ibadan, Curtin University, University of Edinburgh, SUNY Upstate Medical University, Universitätsmedizin Greifswald, Universität Greifswald, Medical University of Graz, University of Maryland, College Park, Monash University, Institut des Maladies Neurodégénératives, Johns Hopkins Medicine, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Hospital for Sick Children, The Lundquist Institute, Harbor–UCLA Medical Center, Boston Medical Center, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $11,390
Funders: U.S. Department of Defense, Foundation for the National Institutes of Health, Howard Hughes Medical Institute, U.S. Department of Veterans Affairs, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Massachusetts General Hospital, Biogen, University of Southern California, BrightFocus Foundation, Office of Research and Development, Vanderbilt University, University of Miami, McLean Hospital, F. Hoffmann-La Roche, Meso Scale Diagnostics, Texas Tech University, School of Medicine, Boston University, Washington University in St. Louis, Univerzita Karlova v Praze, Fundación BBVA, BioClinica, Itä-Suomen Yliopisto, University of Washington, Novartis Pharmaceuticals Corporation, Rush University, University of South Florida, University of North Texas, National Institute for Social Care and Health Research, South London and Maudsley NHS Foundation Trust, Northern California Institute for Research and Education, Yrjö Jahnssonin Säätiö, Wellcome Trust, Università degli Studi di Cagliari, EU Joint Programme – Neurodegenerative Disease Research, Consortium canadien en neurodégénérescence associée au vieillissement, Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease, Université de Lille, Alzheimer's Society, Dipartimenti di Eccellenza, Alzheimer's Research Trust, York University, National Institute for Health and Care Research, Higher Education Funding Council for Wales, Motor Neurone Disease Association, University of Cambridge, University of Southampton, King's College London, Newcastle University, European Commission, University of Nottingham, Cardiff University, National Research Foundation, Universität Heidelberg, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Ministerstvo Školství, Mládeže a Tělovýchovy, AXA Research Fund, Academy of Finland, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Stichting MS Research, Suomen Kulttuurirahasto, Fonds Wetenschappelijk Onderzoek, Ministero della Salute, Ministerstvo Zdravotnictví Ceské Republiky, Ministerio de Economía y Competitividad, Ministero dell’Istruzione, dell’Università e della Ricerca, Lundbeckfonden, Eisai, Juho Vainion Säätiö, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, Novo Nordisk, Stockholms Läns Landsting, Vetenskapsrådet, North Bristol NHS Trust, Banco Bilbao Vizcaya Argentaria, National and Kapodistrian University of Athens, Deutsches Zentrum für Neurodegenerative Erkrankungen, Socialdepartementet, Sahlgrenska Universitetssjukhuset, Universitat de Barcelona, Sigrid Juséliuksen Säätiö, Fundación Salud 2000, Universiteit Antwerpen, Universität zu Köln, Rheinische Friedrich-Wilhelms-Universität Bonn, Universität Duisburg-Essen, Hersenstichting, University College London Hospitals NHS Foundation Trust, Harokopio University, Servier, Vlaamse regering, H. Lundbeck A/S, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Stichting ALS Nederland, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, IXICO, Ludwig Boltzmann Gesellschaft, Grifols, UK Dementia Research Institute, Région Normandie, Associazione Italiana Ricerca Alzheimer, Sorbonne Université, Seinäjoen Keskussairaala, Demensfonden, Fondation pour la Recherche sur Alzheimer, National Institutes of Health, Genentech, University of California, Los Angeles, University of California, Davis, University of North Carolina at Chapel Hill, University of California, San Diego, University of California, Irvine, Wake Forest School of Medicine, Leonard M. Miller School of Medicine, Leonard M. Miller School of Medicine, University of Miami, Canadian Institutes of Health Research, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, National Health and Medical Research Council, Fundação para a Ciência e a Tecnologia, Instituto de Salud Carlos III, European Regional Development Fund, Center for Innovative Medicine, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Institute on Minority Health and Health Disparities
Awards: G100845555, G1012222616, G1023702118, G1045600774, G104586243, G1072871761, G1075404386, G1154988614, G1158107345, G1188945720, Neurocognitive disorders in the elderly, G125972088, G1261314546, UK Dementias Platform, Kompetenznetz 'Demenzen', G1298807586, G1390751753, G1417337112, G1460529261, G1505007571, G1517644521, G1549301130, G1552314173, G1554142629, G1575657597, G1588685326, G1591652791, G1593117279, G1602390028, G1637266829, G1650819308, G1660387998, G171348792, Defining Genetic, Polygenic and Environmental Risk for Alzheimer's Disease using multiple powerful cohorts, focussed Epigenetics and Stem cell metabolomics, G1770719414, G1776849529, G1788709799, G1823308732, G1823779401, G1880935189, G1951116564, Alzheimer's Disease Neuroimaging Initiative, G2009882063, G20300921, G2038718543, Enfermedad de parkinson y deterioro cognitivo: identificación de marcadores genéticos predictivos mediante secuenciación masiva, Verbundprojekt: Bedarf, Inanspruchnahme von Versorgungsleistungen, direkte Kosten und gesundheitsbezogene Lebensqualität bei hochaltrigen Hausarztpatienten (85+) - AgeQualiDe-Studie, Teilprojekt: TU München, G2076520454, G2100670906, G2105457377, Verbundprojekt: Kompetenznetz Demenzen - Epidemiologie: Teilprojekt der TU München, G2144526411, G2152643862, G2189010064, G2340207221, Verbundprojekt Kompetenznetz Demenzen: Teilprojekte der Uni Hamburg (2. Förderphase), La estructura cerebral y el metabolismo en la enfermedad de Alzheimer preclínica. Interacciones entre nuevos y viejos biomarcadores, G2377181310, G2410096279, G2471646051, G250621538, G2522063444, G2539650318, Verbundprojekt Kompetenznetz Demenzen: Teilprojekt der MHH (2. Förderphase), G255803252, G2620658983, G2621534636, G2636645585, Estudio comparativo de portadores de mutaciones determinantes de enfermedad de Alzheimer y demencia frontotemporal genéticas en un modelo de línea celular linfoblastoide y cerebro, G2651015397, G2708544407, G270907595, G271859760, G278200998, G2800149121, G2822345846, G2923850474, G2933281967, G3056018450, G3108940385, Understanding the evolutionary mechanisms of invasion success: Selective footprints in the genome of an Euro-invader – the raccoon dog (Nyctereutes procyonoides), G3130427885, G3131374986, G3146424788, G3220743633, Verbundprojekt Kompetenznetz Demenzen: Teilprojekte der Universität Düsseldorf (2. 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OpenAlex ID: W4223591189