Work

Anaplastic Thyroid Carcinoma With Ilium and Cervical Lymph Nodes Metastases: A Case Report and Literature Review

Year: 2022

Type: preprint

Abstract: IntroductionAnaplastic thyroid carcinoma (ATC) is a rare and clinically aggressive thyroid carcinoma with highly mortality. However, no matter the diagnosis or therapy of this disease was still a dilemma.Case reportWe present a 79-year-old female patient with progressively enlarged thyroid nodules and diagnosed as tracheal stenosis. Two years ago, the patient had presented in our hospital with right ilium pain and diagnosed as poorly differentiated squamous cell carcinoma of lung with right ilium and cervical lymph nodes metastases. Then, the patient received intensity-modulated radiotherapy (IMRT) and cancer immunotherapy with pembrolizumab. Twenty months later, a total thyroidectomy and cervical lymph nodes dissection were undertaken, the histopathologic and immunohistochemical evaluations confirmed the diagnosis of ATC with local squamous cell carcinoma differentiation. Postoperatively, the patient received a cancer immunotherapy with anlotinib and envafolimab, but the patient died 6 weeks after surgery.ConclusionWe have reported a case of ATC with local squamous cell carcinoma differentiation, which was misdiagnosed as lung squamous cell carcinoma with extensive metastases and treated by cancer immunotherapy, the overall survival of this patient was more than 24 months.

Source: Research Square

DOI: 10.21203/rs.3.rs-1528699/v1