Work

Ayurveda interventions for Gout: A systematic review

Year: 2022

Type: preprint

Abstract: BackgroundPatients with Gout frequently use Complementary and Alternative Medicines (CAM therapies), which include Ayurveda medications and treatment procedures, and hence it is essential to determine their safety and efficacy/effectiveness.ObjectivesA systematic review of the published clinical data in view of the safety and efficacy/effectiveness of Ayurvedic treatment protocols in Gout viz-a-viz Vatarakta.MethodsWe searched the PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials: Issue 6 of 12, June 2018), Google Scholar, AYUSH Research Portal (Govt. of India), DHARA, Ancient Science of Life, Shodhganga@INFLIBNET, Online clinical trial registers, and grey literature available from Government Ayurveda College, Trivandrum (Manual search) IPGT & RA, Gujrat Ayurveda University. We excluded abstract-only publications. We could not do a meta-analysis due to the unavailability of relevant studies. Study eligibility criteria: Cases diagnosed as Gout by laboratory findings and/or clinical symptoms, who underwent Ayurvedic treatment/Cases clinically diagnosed as Vatarakta, who underwent Ayurvedic treatment. Participants and interventions and controls: We included participants of either sex satisfying the inclusion criteria who underwent Ayurvedic treatment either Randomized controlled trials (RCTs), Quasi-Experimental Trials, Single group clinical trials, Comparative Clinical Trials (CCTs), and Pragmatic trials.ResultsA total of 398 potentially relevant studies were found, and 21studies met the inclusion criteria, among which ten studies were pre-post studies, seven studies were included among Randomized Comparative Clinical Trials, and four were among Comparative clinical trials.Conclusions and implications of key findingsEven though Ayurveda physicians are pragmatically treating/rehabilitating Vatarakta/Gout cases and reported satisfactory results in terms of both safety and efficacy/effectiveness, this review is unable to produce strong valid evidence to prove the efficacy/effectiveness and safety of Ayurveda over Non-Ayurveda interventions or Placebo due to lack of quality and unavailability of published works. So the authors propose well-organized and methodologically sound quality research works in this regard.Systematic review registration number- PROSPERO (CRD42019131198)

Source: Research Square

DOI: 10.21203/rs.3.rs-1504922/v2